Klassische Synthese von Thymopoietin 32-36 (TP 5) unter Verwendung der säurelabilen 1- (1 -Adamantyl) -1 -methylethoxycarbonyl- Schutzgruppe+ / Conventional Synthesis of Thymopoietin 32-36 (TP 5) Using the 1 -(1 - Adamantyl)-1 -methylethoxycarbonyl Group
- Resource Type
- Article
- Authors
- Heinzel, Wolfgang; Kronbach, Thomas; Voelter, Wolfgang
- Source
- Zeitschrift für Naturforschung B; December 1982, Vol. 37 Issue: 12 p1652-1658, 7p
- Subject
- Language
- ISSN
- 09320776; 18657117
A synthesis of high yields of TP 5 is described. The a-amino functions were blocked by the acid-labile 1-(1 -adamantyl)-1-methylethoxycarbonyl-(Adpoc)group. The Adpoc group is cleaved under mild acidolytic conditions with 3% TFA in CH2CI2while the tert-butyl residues remained intact. This selective cleavage of the Adpoc group compared with the Boc and tert-butyl residues allows new strategies for the synthesis of large peptides