Preparation of the 4-Hydroxytryptamine Scaffold via Palladium-Catalyzed Cyclization: A Practical and Versatile Synthesis of Psilocin
- Resource Type
- Article
- Authors
- Gathergood, N.; Scammells, P. J.
- Source
- Organic Letters; March 2003, Vol. 5 Issue: 6 p921-923, 3p
- Subject
- Language
- ISSN
- 15237060; 15237052
The 4-hydroxytryptamine scaffold of psilocin was successfully prepared via palladium-catalyzed cyclization of protected N-tert-butoxycarbonyl-2-iodo-3-methoxyaniline and an appropriately substituted silyl acetylene. Removal of the protecting groups afforded psilocin in good yield.