Enantioselective Access to Isoquinuclidines by Tropenone Desymmetrization and Homoallylic Radical Rearrangement: Synthesis of (+)-Ibogamine
- Resource Type
- Article
- Authors
- Hodgson, D. M.; Galano, J.-M.
- Source
- Organic Letters; May 2005, Vol. 7 Issue: 11 p2221-2224, 4p
- Subject
- Language
- ISSN
- 15237060; 15237052
Chiral lithium amide-induced desymmetrization of a tropenone and subsequent Bu3SnH-catalyzed nitrogen-directed homoallylic radical rearrangement constitute key steps in a new strategy to dehydroisoquinuclidines. The strategy was applied in a synthesis of (+)-ibogamine.