Interleukin-17A- or tumor necrosis factor α-mediated increase in proliferation of T cells cocultured with synovium-derived mesenchymal stem cells in rheumatoid arthritis
- Resource Type
- Article
- Authors
- Zhang, Zhengzheng; Ding, Yuanjing; Li, Weiping; Song, Bin; Yang, Rui
- Source
- Arthritis Research & Therapy (formerly Arthritis Research); October 2013, Vol. 15 Issue: 5 pR169-R169, 1p
- Subject
- Language
- ISSN
- 14786354; 14786362
Mesenchymal stem cells (MSCs) represent promising applications in rheumatoid arthritis (RA). However, the inflammatory niche in the RA synovium could adversely affect MSC function. This study was designed to investigate biologic and immunologic properties of synovium-derived MSCs (SMSCs) in RA, with particular focus on whether cytokines can mediate increase of proliferation of T cells cocultured with SMSCs in RA.