Purpose: To evaluate the effect of compressive axial loading in imaging of the lumbar spine in patients with clinically suspected spinal stenosis.Material and Methods: A total of 84 patients were examined, 50 with CT (after intrathecal contrast administration) and 34 with MR. First the dural sac cross-sectional area (CSA) was determined with the patient in the supine psoas relaxed position (PRP). Then the CSA was determined during supine axial compression in slight extension (ACE), obtained with a specially designed loading device. A measurement error study was performed.Results: A minimum difference in CSA of 15 mm2between PRP and ACE was found to be significant. In 4050 (80) of CT-examined patients and in 2634 (76) of MR-examined patients a significant difference in CSA was found. In 2584 (30) of the patients there was a significant difference at more than one level.Conclusion: for an adequate evaluation of the CSA, CT or MR studies should be performed with axial loading in patients who have symptoms of lumbar spinal stenosis.