Candida albicans, a common fungal pathogen that can cause opportunistic infections, is regarded as an apparently asexual, diploid fungus. A parasexual cycle was previously found between homozygotes with opposite mating type-like loci (MTLa/α). Fluconazole-resistant strains had a higher proportion of MTLhomozygotes, whereas MTLhomozygous C. albicanswas found in only about 3.2% of clinical strains. MTLheterozygotes had a low frequency (1.4 × 10−4) of white–opaque switching to MTLhomozygotes in nature.