Inhibition of voltage-gated Na+currents by eleclazine in rat atrial and ventricular myocytes
- Resource Type
- Article
- Authors
- Caves, Rachel E.; Carpenter, Alexander; Choisy, Stéphanie C.; Clennell, Ben; Cheng, Hongwei; McNiff, Cameron; Mann, Brendan; Milnes, James T.; Hancox, Jules C.; James, Andrew F.
- Source
- Heart Rhythm O2; August 2020, Vol. 1 Issue: 3 p206-214, 9p
- Subject
- Language
- ISSN
- 26665018
Atrial-ventricular differences in voltage-gated Na+currents might be exploited for atrial-selective antiarrhythmic drug action for the suppression of atrial fibrillation without risk of ventricular tachyarrhythmia. Eleclazine (GS-6615) is a putative antiarrhythmic drug with properties similar to the prototypical atrial-selective Na+channel blocker ranolazine that has been shown to be safe and well tolerated in patients.