Near-infrared (NIR) light-driven water splitting to produce hydrogen (H2) has long been of great interest in photocatalysis, but it remains a formidable challenge so far due to both kinetic and thermodynamic shortcomings. To break through this limitation, we demonstrate a noble metal-free two-dimensional ZnIn2S4-based photocatalyst rich in sulfur vacancies viaa facile hydrothermal method and firstly realized NIR-driven H2production beyond 800 nm using single component ZnIn2S4-based materials. We disclosed the existence of an efficient Urbach tail transition to absorb long-wavelength NIR light according to the valence-band spectra, ultraviolet-visible-NIR diffuse reflectance spectra, steady-state photoluminescence spectra, transient photocurrent response, and electron paramagnetic resonance measurements. The successful construction of sulfur vacancies in ZnIn2S4nanosheets not only extends the spectral absorption range but also has an excellent carrier diffusion property as well as an abundance of active sites. Therefore, our findings may provide an effective and promising perspective for the future development of NIR-responsive ZnIn2S4-based photocatalysts for highly efficient H2production.