Vitality and well-being of employees are attributed to productivity, employee performance, and quality of life. By considering the stressful and impactful service provided as healthcare workers, this research aims to establish whether a nurse's personal energy/vitality directly contributes to, and predicts their level of well-being. Data were collected from Mexico (n = 209) and Canada (n = 303) and structural equation modelling was employed for analysis. The findings revealed a strong positive relationship (γCanada= 0.72, γMexico= 0.66) between the two constructs indicating that people with a high (low) level of personal energy will also experience a high (low) level of well-being. Having demonstrated the impact of personal energy on well-being, this research lays the foundations for a much larger framework that can examine the significance of individual mental health constructs and their ability to drain, maintain or potentially gain personal energy/vitality and ultimately their effect on well-being.