Association of APOEpolymorphisms with disease severity in MS is limited to women
- Resource Type
- Article
- Authors
- Kantarci, O.H.; Hebrink, D.D.; Achenbach, S.J.; Pittock, S.J.; Altintas, A.; Schaefer-Klein, J.L.; Atkinson, E.J.; de Andrade, M.; McMurray, C.T.; Rodriguez, M.; Weinshenker, B.G.
- Source
- Neurology (Ovid); March 2004, Vol. 62 Issue: 5 p811-814, 4p
- Subject
- Language
- ISSN
- 00283878; 1526632X
The authors studied the association of an exon 4 (E42/3/4) and three promoter polymorphisms of APOEwith disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E42 allele took longer to attain an Expanded Disability Status Scale score of 6 (p0.015) and had more favorable ranked severity scores than noncarriers (p0.009). There was no association in men. Alleles 3 or 4 and promoter polymorphisms were not associated with disease course or severity.