For chronic critical illness patients with cognitive impairment disorders (post cardiopulmonary resuscitation [PCR] and hypoxic brain syndrome), infections caused by resistant microorganisms in intensive care units (ICUs) bring the greatest challenges. In this study, the evaluation the journey of the use of simple to broad spectrum antibiotherapies for sensitive to multi drug resistant microorganism in those patients during ICU stay. And also we aimed to reviewed the outcome of futile treatment.