A small-molecule antivirulence agent for treating Clostridium difficile infection.
- Resource Type
- Article
- Authors
- Bender, Kristina Oresic; Garland, Megan; Ferreyra, Jessica A.; Hryckowian, Andrew J.; Child, Matthew A.; Puri, Aaron W.; Solow-Cordero, David E.; Higginbottom, Steven K.; Segal, Ehud; Banaei, Niaz; Shen, Aimee; Sonnenburg, Justin L.; Bogyo, Matthew
- Source
- Science Translational Medicine; 9/23/2015, Vol. 7 Issue 306, p1-11, 11p, 1 Color Photograph, 5 Graphs
- Subject
- CLOSTRIDIOIDES difficile
CYSTEINE proteinases
ANTIBIOTICS
DIARRHEA
PSEUDOMEMBRANOUS enterocolitis
THERAPEUTICS
- Language
- ISSN
- 19466234
The article focuses on the treatment of Clostridium difficile infection. Topics discussed include pharmacological targeting of the cysteine protease domain within the same; impact of non-antibiotic drug on pathology of disease; and association of Clostridium difficile infection with nosocomial diarrhea and pseudomembranous colitis.