Altered glycosyltransferases in colorectal cancer.
- Resource Type
- Editorial
- Authors
- Venkitachalam, Srividya; Guda, Kishore
- Source
- Expert Review of Gastroenterology & Hepatology; Jan2017, Vol. 11 Issue 1, p5-7, 3p
- Subject
- NUCLEOTIDE sequence
COLON cancer
GENETIC mutation
GLYCOSYLATION
MUCINS
CANCER cells
- Language
- ISSN
- 17474124
The authors discuss the use of targeted next-generation sequencing to characterize colorectal cancer (CRC)-related mutational alterations in genes encoding glycosylation enzymes. Topics include various genes that showed mutational alterations in CRCs with 12 genes exhibiting higher mutation rates, the hypoglycosylation of Mucin-1 protein, and the migration of colon cancer cells.