CHANGES IN GENE EXPRESSION FOLLOWING CARDIAC PACING-INDUCED DELAYED CARDIOPROTECTION IN THE CANINE HEART.
- Resource Type
- Article
- Authors
- KOVÁCS, MÁRIA; PAPP, RITA; VARGA-ORVOS, Z.; MÉNESI, DALMA; PUSKÁS, L. G.; VÉGH, ÁGNES
- Source
- Acta Biologica Hungarica; Dec2010, Vol. 61 Issue 4, p434-448, 15p, 2 Charts, 2 Graphs
- Subject
- GENE expression
MYOCARDIAL depressants
CARDIAC pacing
DNA microarrays
MUTTS (Dogs)
PROTEIN synthesis
LABORATORY dogs
- Language
- ISSN
- 02365383
The article discusses a study on the changes in gene expression that occur 24 hours after preconditioning that may relate to delayed antiarrhythmic protection. The experiments used cDNA microarrays and quantitative real-time (QRT)-PCR techniques in established canine model of ischaemia and reperfusion. Adult mongrel dogs with mean body weight of around 18 kilograms were used. It suggests that changes in gene expression are not invariably associated with changes in protein synthesis and do not reflect changes occurring at protein level.