Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults.
- Resource Type
- Article
- Authors
- Ogwang, Caroline; Kimani, Domtila; Edwards, Nick J.; Roberts, Rachel; Mwacharo, Jedidah; Bowyer, Georgina; Bliss, Carly; Hodgson, Susanne H.; Njuguna, Patricia; Viebig, Nicola K.; Nicosia, Alfredo; Gitau, Evelyn; Douglas, Sandy; Illingworth, Joe; Marsh, Kevin; Lawrie, Alison; Imoukhuede, Egeruan B.; Ewer, Katie; Urban, Britta C.; Hill, Adrian V. S.
- Source
- Science Translational Medicine; 5/6/2015, Vol. 7 Issue 286, p1-8, 8p, 3 Charts, 3 Graphs
- Subject
- VACCINATION
ADENOVIRUSES
AMINO acid sequence
THROMBOSPONDINS
ANTIMALARIALS
POLYMERASE chain reaction
PLASMODIUM falciparum
- Language
- ISSN
- 19466234
The article looks at a study regarding vaccination with the recombinant viral vectors chimpanzee adenovirus 63 and modified vaccinia Ankara encoding the malaria peptide sequence multiple epitope string and thrombospondin-related adhesion protein (ME-TRAP). It mentions antimalarials to clear parasitemia and conducted polymerase chain reaction (PCR) with the malaria parasite Plasmodium falciparum. It also mentions vaccination reduced the risk of infection.