Reduction of Egf Signaling Decides Transition From Crown to Root in the Development of Mouse Molars.
- Resource Type
- Article
- Authors
- FUJIWARA, NAOKI; AKIMOTO, TADASHI; OTSU, KEISHI; KAGIYA, TADAYOSHI; ISHIZEKI, KIYOTO; HARADA, HIDEMITSU
- Source
- Journal of Experimental Zoology Part B: Molecular & Developmental Evolution; 7/15/2009, Vol. 312B Issue 5, p486-494, 9p, 6 Diagrams
- Subject
- EPIDERMAL growth factor
GROWTH factors
MOLARS
TEETH
DENTAL enamel
EPITHELIAL cells
- Language
- ISSN
- 15525007
The article presents a study which investigated the change in epidermal growth factor (Egf) signaling during the transition from crown to root in the development of mouse molars. Immunohistochemical studies revealed that the expression of Egf receptors in the enamel organ disappear in the process and are not seen in Hertwig's epithelial root sheath (HERS). According to the study, in the presence of Egf, stellate reticulum (SR) cells located between the inner and outer epithelial layers in the enamel organ actively proliferated and maintained the enamel organ and the formation of HERS was not evident.