Immunoglobulin-Driven Complement Activation Regulates Pro-Inflammatory Remodeling in Pulmonary Hypertension.
- Resource Type
- Article
- Authors
- Frid, Maria G.; McKeon, B. Alexandre; Thurman, Joshua M.; Maron, Bradley A.; Min Li; Hui Zhang; Kumar, Sushil; Sullivan, Timothy; Laskowsky, Jennifer; Fini, Mehdi A.; Samantha Hu; Tuder, Rubin M.; Gandjeva, Aneta; Wilkins, Martin R.; Rhodes, Christopher J.; Ghataorhe, Pavandeep; Leopold, Jane A.; Rui-Sheng Wang; Holers, V. Michael; Stenmark, Kurt R.
- Source
- American Journal of Respiratory & Critical Care Medicine; 1/15/2020, Vol. 201 Issue 2, pE1-E28, 28p
- Subject
- IMMUNOGLOBULINS
PULMONARY hypertension
LABORATORY rodents
STAINS & staining (Microscopy)
POLYMERASE chain reaction
- Language
- ISSN
- 1073449X
The article present a study on immunoglobulin-driven complement activation which regulates pro-inflammatory remodeling in pulmonary hypertension. Topics discussed include using two rodent models (mice and rats) to expand experimental findings cross-species; in vivo right ventricular systolic pressure (RVSP) assessment; and immunofluorescent (IF) and iImmunohistochemical (IHC) staining. Also mentions about the use of real-time Polymerase chain reaction (PCR).