Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication.
- Resource Type
- Article
- Authors
- Subramaniyan, Bharathiraja; Larabee, Jason L.; Bodas, Manish; Moore, Andrew R.; Burgett, Anthony W. G.; Papin, James F.; Walters, Matthew S.
- Source
- American Journal of Respiratory Cell & Molecular Biology; Sep2023, Vol. 69 Issue 3, p367-370, 6p
- Subject
- SARS-CoV-2
- Language
- ISSN
- 10441549
The article investigate the role of UCHL1 (ubiquitin C-terminal hydrolase 1) in regulating SARS-CoV-2 infection in human airway epithelial cells. It discusses how inhibiting UCHL1 enzymatic activity with LDN-57444 suppresses SARS-CoV-2 replication in a dose-dependent manner. It also explores the impact of UCHL1 overexpression on virus replication and suggests that targeting UCHL1 activity may lead to the development of antiviral compounds.