Single-Walled Carbon Nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages In Situ.
- Resource Type
- Article
- Authors
- Mangum, James B.; Turpin, Elizabeth A.; Antao-Menezes, Aurita; Cesta, Mark F.; Bermudez, Edilberto; Bonner, James C.
- Source
- Particle & Fibre Toxicology; 2006, Vol. 3, p1-13, 13p
- Subject
- CARBON nanotubes
CHEMICAL vapor deposition
COBALT
MOLYBDENUM
CATALYSTS
HISTOPATHOLOGY
CELL proliferation
- Language
- ISSN
- 17438977
The article discusses a study on the fibrogenic potential of single-walled carbon nanotube (SWCNT) synthesized by chemical vapor deposition with cobalt (Co) and molybdenum (Mo) as catalysts. Lung histopathology, cell proliferation and growth factor mRNAs at 1 and 21 days post exposure were assessed after a single oropharyngeal aspiration of SWCNT in rats. It suggests that only SWCNT caused interstitial fibrotic lesions in the lungs of rats, increases in lung PDGF mRNA levels and formation of carbon bridge structures between alveolar macrophages in situ.