Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism.
- Resource Type
- Article
- Authors
- Karagiannis, George S.; Pastoriza, Jessica M.; Yarong Wang; Harney, Allison S.; Entenberg, David; Pignatelli, Jeanine; Sharma, Ved P.; Xue, Emily A.; Cheng, Esther; D'Alfonso, Timothy M.; Jones, Joan G.; Anampa, Jesus; Rohan, Thomas E.; Sparano, Joseph A.; Condeelis, John S.; Oktay, Maja H.
- Source
- Science Translational Medicine; 7/5/2017, p1-15, 15p
- Subject
- METASTATIC breast cancer
BREAST cancer patients
CANCER treatment
CANCER invasiveness
BREAST cancer treatment
ANTINEOPLASTIC agents
TUMOR microenvironment
- Language
- ISSN
- 19466234
The article discusses the findings of a study which examines the effectiveness of a neoadjuvant chemotherapy as treatment for breast cancer metastasis through a tumor microenvironment of metastasis (TMEM). The study highlights the use of a fixed tissue and intravital imaging of breast cancer patients tumors. It also notes the development of TMEM inhibitor function in improving the benefits of chemotherapy to breast cancer patients.