A Stepwise Increase in Recombinant Human Growth Hormone Dosing During Puberty Achieves Improved Pubertal Growth: A National Cooperative Growth Study Report.
- Resource Type
- Article
- Authors
- Riddick, Linda; Alter, Craig; Davis, D. Aaron; Frane, James; Lippe, Barbara; Bakker, Bert
- Source
- Journal of Pediatric Endocrinology & Metabolism; Jul2009, Vol. 22 Issue 7, p623-628, 6p, 3 Charts, 2 Graphs
- Subject
- STATURE
PUBERTY
RECOMBINANT human somatotropin
HUMAN growth hormone
PEDIATRIC endocrinology
- Language
- ISSN
- 0334018X
The article discusses a study of the near adult height (NAH) improvement of children variedly treated during puberty with increased doses of recombinant human growth hormone (rhGH). It is stated that in patients attaining NAH after three years, an increase of 3.6 centimeters (cm) in mean height gain and an increase of 0.49 in mean height standard dose during puberty was observed. Results showed that in comparison with a fixed dose, increased rhGH doses improved pubertal height gain.