Competing Interests: The authors declared no conflicts of interest associated to this work and no financial interests or commercial benefits associated with the current work. A.F. declares patent applications outside the current work, and leadership in PlantBiosys, Swysh and HumaniThé – biotech start-up companies outside the current work. J.R. declares the CIHR grant “Transgender Youth in Clinical Care: A Pan-Canadian Cohort Study of Medical, Social and Family Outcomes”. J.R. declares stock options in Gilead Sciences outside the current work. R.T. declares speaking fees, Master Clinician Alliance on opioid crisis outside of the current work. R.T. declares unpaid leadership – President (2019-2021) and current board member of the Alberta Pain Society, and past board member of Canadian Society of Addiction Medicine. R.T is a Co-Founder and Chief Medical Officer, The Newly Institute; there is no commercial benefit from this publication. T.J. declares Speaker's Bureau, Advisory Board Honoraria from several companies, all outside the current work. O.K. declares grant from the CIHR “Understanding the sex-specificity of cancer-associated cognitive impairment: from molecular mechanisms to behavioural outcomes” outside the current work. O.K. declares patent applications outside the current work, and leadership in PathwayRx, PlantBiosys, Swysh and HumaniThé – biotech start-up companies outside the current work.