Inhibition of blood group antibodies by soluble substances.
- Resource Type
- Academic Journal
- Authors
- Byrne KM; SBB Program Education Coordinator, National Institutes of Health (NIH) Clinical Center, Department of Transfusion Medicine, 10 Center Drive, Bethesda, MD.; Mercado CMC; Reference Technologist, American Red Cross, Pomona, CA.; Nnabue TN; Training Technologist, Transfusion Medicine, Walter Reed National Military Medical Center.; Paige TD; SBB Program Director and Supervisor of Transfusion Services, National Institutes of Health (NIH) Clinical Center, Department of Transfusion Medicine, Bethesda, MD.; Flegel WA; SBB Program Medical Director, Chief of Laboratory Services Section, National Institutes of Health (NIH) Clinical Center, Department of Transfusion Medicine, Bethesda, MD.
- Source
- Publisher: American Red Cross Country of Publication: United States NLM ID: 8806387 Publication Model: Print Cited Medium: Print ISSN: 0894-203X (Print) Linking ISSN: 0894203X NLM ISO Abbreviation: Immunohematology Subsets: MEDLINE
- Subject
- Language
- English
- ISSN
- 0894-203X
Conclusions: The presence of multiple alloantibodies or an antibody to a highprevalance antigen in a patient sample can pose challenges in antibody identification. The pattern of reactivity seen on an antibody panel may show various strengths of reactivity by different methods of testing or same strength of reactivity at one or more phases of testing. To ensure proper identification, multiple investigative tools may be used. We review one of these methods-inhibition by soluble substances-which has become an expansion of our toolbox within the past 10 years. Alloantibodies can be inhibited using specific soluble substances. These soluble substances occur naturally in various fluids or can be manufactured. When a patient sample contains multiple antibodies, clinically significant or not, inhibition of one may help determine specificities of others. Specific inhibition of a particular antibody will also help to confirm its presence.