Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B.
- Resource Type
- Academic Journal
- Authors
- Low WF; Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500 Petaling Jaya, Selangor, Malaysia.; Ngeow YF; Department of Pre-clinical Sciences, Faculty of Medicine and Health Sciences, University Tunku Abdul Rahman, Jalan Sungai Long, Bandar Sungai Long, Cheras 43000, Kajang, Malaysia.; Chook JB; Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500 Petaling Jaya, Selangor, Malaysia.; Tee KK; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603 Kuala Lumpur, Malaysia.; Ong SK; Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500 Petaling Jaya, Selangor, Malaysia.; Peh SC; Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500 Petaling Jaya, Selangor, Malaysia.; Bong JJ; Sunway Medical Centre, Jalan Lagoon Selatan, Bandar Sunway, 47500 Petaling Jaya, Selangor, Malaysia.; Mohamed R; Department of Medicine, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603 Kuala Lumpur, Malaysia.
- Source
- Publisher: Published by Cambridge University Press in association with the Clinical and Biomedical Computing Unit of the University of Cambridge School of Clinical Medicine Country of Publication: England NLM ID: 100939725 Publication Model: Electronic Cited Medium: Internet ISSN: 1462-3994 (Electronic) Linking ISSN: 14623994 NLM ISO Abbreviation: Expert Rev Mol Med Subsets: MEDLINE
- Subject
- Language
- English
Hepatitis B virus (HBV) infection led to 66% liver deaths world-wide in year 2015. Thirty-seven per cent of these deaths were the result of chronic hepatitis B (CHB)-associated hepatocellular carcinoma (HCC). Although early diagnosis of HCC improves survival, early detection is rare. Methylation of HBV DNA including covalently closed circular DNA (cccDNA) is more often encountered in HCC cases than those in CHB and cirrhosis. Three typical CpG islands within the HBV genome are the common sites for methylation. The HBV cccDNA methylation affects the viral replication and protein expression in the course of infection and may associate with the disease pathogenesis and HCC development. We review the current findings in HBV DNA methylation that provide insights into its role in HCC diagnosis.