Mycobacterium tuberculosis Resides in Macrophages in Laryngeal Tuberculosis: A Case Report.
- Resource Type
- Report
- Authors
- Achache W; MEPHI, Aix-Marseille University, IRD, 13005 Marseille, France.; IHU Méditerranée Infection, 13005 Marseille, France.; Boualam MA; MEPHI, Aix-Marseille University, IRD, 13005 Marseille, France.; IHU Méditerranée Infection, 13005 Marseille, France.; Cassir N; MEPHI, Aix-Marseille University, IRD, 13005 Marseille, France.; IHU Méditerranée Infection, 13005 Marseille, France.; Mimari C; Service ORL Hôpital de la Conception, 13005 Marseille, France.; Poitrenaud D; Service Maladies Infectieuses, CH Ajaccio, 20000 Ajaccio, France.; Mezouar S; MEPHI, Aix-Marseille University, IRD, 13005 Marseille, France.; IHU Méditerranée Infection, 13005 Marseille, France.; Mège JL; MEPHI, Aix-Marseille University, IRD, 13005 Marseille, France.; IHU Méditerranée Infection, 13005 Marseille, France.; Drancourt M; MEPHI, Aix-Marseille University, IRD, 13005 Marseille, France.; Lepidi H; MEPHI, Aix-Marseille University, IRD, 13005 Marseille, France.; IHU Méditerranée Infection, 13005 Marseille, France.
- Source
- Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2076-0817
Laryngeal tuberculosis is a rare form of extrapulmonary tuberculosis that questions the natural history of this infection. We report one such case in which a pathological examination of a laryngeal biopsy revealed granulomatous inflammation with caseous necrosis. Further investigations combining immunofluorescence detection of macrophages and in situ hybridization of Mycobacterium tuberculosis indicated the presence of Mycobacterium tuberculosis ( M. tuberculosis ) in laryngeal granulomatous inflammatory lesions. This observation suggests that the natural history of laryngeal tuberculosis does not differ from that of other forms, guiding early diagnosis in patients with laryngeal lesions to ensure appropriate check-ups and treatment.