ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends.
- Resource Type
- Academic Journal
- Authors
- Aprison EZ; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.; Ruvinsky I; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
- Source
- Publisher: Caltech Library Country of Publication: United States NLM ID: 101759238 Publication Model: eCollection Cited Medium: Internet ISSN: 2578-9430 (Electronic) Linking ISSN: 25789430 NLM ISO Abbreviation: MicroPubl Biol Subsets: PubMed not MEDLINE
- Subject
- Language
- English
Valence of animal pheromone blends can vary due to differences in relative abundance of individual components. For example, in C. elegans , whether a pheromone blend is perceived as "male" or "hermaphrodite" is determined by the ratio of concentrations of ascr#10 and ascr#3. The neuronal mechanisms that evaluate this ratio are not currently understood. We present data that suggest that the function of guanylyl cyclase ODR-1 in AWB neurons is required for the effect of ascr#3 that counteracts the activity of ascr#10. This finding defines a new module in the neuronal mechanism that determines the sexual identity of C. elegans pheromone.
(Copyright: © 2022 by the authors.)