Clinical validation of a ctDNA-Based Assay for Multi-Cancer Detection: An Interim Report from a Vietnamese Longitudinal Prospective Cohort Study of 2795 Participants.
- Resource Type
- Academic Journal
- Authors
- Nguyen THH; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Lu YT; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Medical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Le VH; Department of General Planning and General Affaire, National Cancer Hospital, Hanoi, Vietnam.; Bui VQ; Department of Radiation Therapy, Hanoi Oncology Hospital, Hanoi, Vietnam.; Nguyen LH; Department of Cardiology, Hanoi Medical University, Hanoi, Vietnam.; Pham NH; Gastroenterology Department, Hue Central Hospital, Hue, Vietnam.; Phan TH; Director Board, Medic Medical Center, Ho Chi Minh, Vietnam.; Nguyen HT; Out-patient health care services department, University Medical Center HCM, Ho Chi Minh, Vietnam.; Tran VS; Director Board, People's Hospital 115, Ho Chi Minh, Vietnam.; Bui CV; Board of Management, Xuyen A General Hospital, Ho Chi Minh, Vietnam.; Vo VK; Director of Cantho Oncology Hospital, Vietnam, Cantho Oncology Hospital, Can Tho, Vietnam.; Nguyen PTN; General Planning Department, Danang Oncology Hospital, Da Nang, Vietnam.; Dang HHP; Interventional Cardiology Department, Dongnai General Hospital, Dong Nai, Vietnam.; Pham VD; Director Board, Thong Nhat Dongnai General Hospital, Dong Nai, Vietnam.; Cao VT; Department of Cardiology, Le Van Thinh Hospital, Ho Chi Minh, Vietnam.; Nguyen TD; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Data Department, Gene Solutions, Ho Chi Minh, Vietnam.; Nguyen LHD; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Medical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Phan NM; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Medical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Nguyen TH; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Data Department, Gene Solutions, Ho Chi Minh, Vietnam.; Nguyen VTC; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Pham TMQ; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Tran VU; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Le MP; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Vo DH; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Tran TMT; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Nguyen MN; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Nguyen TT; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Medical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Tieu BL; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Medical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Nguyen HTP; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Clinical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Truong DYA; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Clinical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Cao CTT; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Clinical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Nguyen VT; Breast Cancer Department, National Cancer Hospital, Hanoi, Vietnam.; Le TLQ; Lung Cancer Department, Hanoi Oncology Hospital, Hanoi, Vietnam.; Luong TLA; Center of clinical genetics and genomics Vietnam, Hanoi Medical University, Hanoi, Vietnam.; Doan TKP; Center of clinical genetics and genomics Vietnam, Hanoi Medical University, Hanoi, Vietnam.; Dao TT; Center of clinical genetics and genomics Vietnam, Hanoi Medical University, Hanoi, Vietnam.; Phan CD; Oncology Department, Hue Central hospital, Hue, Vietnam.; Nguyen TX; General Surgery Department, Hue Central hospital, Hue, Vietnam.; Pham NT; Oncology Department, Hue Central hospital, Hue, Vietnam.; Nguyen BT; Laboratory Department, Medic Medical Center, Ho Chi Minh, Vietnam.; Pham TTT; Hepatology Department, Medic Medical Center, Ho Chi Minh, Vietnam.; Le HL; Respiratory Clinic, Medic Medical Center, Ho Chi Minh, Vietnam.; Truong CT; Outpatient Department, Medic Medical Center, Ho Chi Minh, Vietnam.; Jasmine TX; Ultrasound Department, Medic Medical Center, Ho Chi Minh, Vietnam.; Le MC; Health care services Department, University Medical Center HCM, Ho Chi Minh, Vietnam.; Phan VB; Board of Management, People's Hospital 115, Ho Chi Minh, Vietnam.; Truong QB; Cardiology Center, University Medical Center HCM, Ho Chi Minh, Vietnam.; Tran THL; General Planning Department, Cantho Oncology Hospital, Can Tho, Vietnam.; Huynh MT; General Planning Department, Cantho Oncology Hospital, Can Tho, Vietnam.; Tran TQ; General Surgery Department, Danang Oncology Hospital, Da Nang, Vietnam.; Nguyen ST; Microbiology Department, Thong Nhat Dongnai General Hospital, Dong Nai, Vietnam.; Tran V; Oncology Department, Thong Nhat Dongnai General Hospital, Dong Nai, Vietnam.; Tran VK; Director Board, Le Van Thinh Hospital, Ho Chi Minh, Vietnam.; Nguyen HN; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Director Board, Gene Solutions, Ho Chi Minh, Vietnam.; Nguyen DS; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Medical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Nguyen TQT; Clinical Department, Medical Genetics Institute, Ho Chi Minh, Vietnam.; Phan TV; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Clinical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Do TT; Director Board, Medical Genetics Institute, Ho Chi Minh, Vietnam.; Truong DK; Director Board, Medical Genetics Institute, Ho Chi Minh, Vietnam.; Tang HS; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Medical Department, Gene Solutions, Ho Chi Minh, Vietnam.; Phan MD; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Data Department, Gene Solutions, Ho Chi Minh, Vietnam.; Giang H; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Data Department, Gene Solutions, Ho Chi Minh, Vietnam.; Nguyen HN; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.; Tran LS; Research and Development Department, Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.
- Source
- Publisher: Taylor & Francis Country of Publication: England NLM ID: 8307154 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4192 (Electronic) Linking ISSN: 07357907 NLM ISO Abbreviation: Cancer Invest Subsets: MEDLINE
- Subject
- Language
- English
The SPOT-MAS assay "Screening for the Presence Of Tumor by Methylation And Size" detects the five most common cancers in Vietnam by evaluating circulating tumor DNA in the blood. Here, we validated its performance in a prospective multi-center clinical trial, K-DETEK. Our analysis of 2795 participants from 14 sites across Vietnam demonstrates its ability to detect cancers in asymptomatic individuals with a positive predictive value of 60%, with 83.3% accuracy in detecting tumor location. We present a case report to support further using SPOT-MAS as a complementary method to achieve early cancer detection and provide the opportunity for early treatment.