The use of rats to detect drug-resistant TB.
- Resource Type
- Academic Journal
- Authors
- Beyene N; Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) TB Research Project, Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia.; APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania.; Department of Biology, University of Antwerp, Belgium.; Sitotaw AL; Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) TB Research Project, Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia.; Telila EG; Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) TB Research Project, Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia.; Gebre HA; Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) TB Research Project, Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia.; Alemu NB; Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) TB Research Project, Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia.; Burny R; APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania.; APOPO, Research Project, Eduardo Mondlane University, Maputo, Mozambique.; Cox C; APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania.; Department of Biology, University of Antwerp, Belgium.; Soka J; APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania.; APOPO, Research Project, Tanzanian Veterinary Research Institute, Dar es Salaam, Tanzania.; Tegegn B; Addis Ababa City Administration Health Bureau, Tuberculosis/HIV, Addis Ababa, Ethiopia.; Wassie L; AHRI, Mycobacterium, Diseases Research Directorate, Addis Ababa, Ethiopia.; Bobosha K; AHRI, Mycobacterium, Diseases Research Directorate, Addis Ababa, Ethiopia.; Agizew T; Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) TB Research Project, Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia.; APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania.; Department of Biology, University of Antwerp, Belgium.
- Source
- Publisher: International Union Against Tuberculosis and Lung Disease Country of Publication: France NLM ID: 101624961 Publication Model: Print Cited Medium: Print ISSN: 2220-8372 (Print) Linking ISSN: 22208372 NLM ISO Abbreviation: Public Health Action Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2220-8372
Although detection of drug-susceptible TB by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling-trained African giant pouched rats has been known for more than a decade, the detection of drug-resistant TB (DR-TB) using rats has never been explored before. We present what we believe to be the first report on rifampicin-resistant TB (RR-TB) detected using Xpert® MTB/RIF Ultra, comparably identified by rats sniffing sputum samples from presumptive TB patients: 88% of RR-TB detected using Ultra were identified by the rats. Further evaluation of the usefulness of rats for large-scale DR-TB contact triage testing is needed, especially in low- and middle-income countries, where resources are limited.
Competing Interests: Conflicts of interest: none declared.
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