Association of Radiation Dose to the Amygdala-Orbitofrontal Network with Emotion Recognition Task Performance in Patients with Low-Grade and Benign Brain Tumors.
- Resource Type
- Academic Journal
- Authors
- Hardy SJ; Department of Radiation Oncology, University of Rochester, Rochester, NY 14620, USA.; Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Finkelstein A; Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.; Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Milano MT; Department of Radiation Oncology, University of Rochester, Rochester, NY 14620, USA.; Schifitto G; Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.; Sun H; Department of Surgery, Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY 14642, USA.; Holley K; Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.; Usuki K; Department of Radiation Oncology, University of Rochester, Rochester, NY 14620, USA.; Weber MT; Department of Surgery, Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Zheng D; Department of Radiation Oncology, University of Rochester, Rochester, NY 14620, USA.; Seplaki CL; Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.; Office for Aging Research and Health Services, University of Rochester Medical Center, Rochester, NY 14642, USA.; Janelsins M; Department of Radiation Oncology, University of Rochester, Rochester, NY 14620, USA.; Department of Surgery, Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY 14642, USA.
- Source
- Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2072-6694
Background: Although data are limited, difficulty in social cognition occurs in up to 83% of patients with brain tumors. It is unknown whether cranial radiation therapy (RT) dose to the amygdala-orbitofrontal network can impact social cognition.
Methods: We prospectively enrolled 51 patients with low-grade and benign brain tumors planned for cranial RT. We assessed longitudinal changes on an emotion recognition task (ERT) that measures the ability to recognize emotional states by displaying faces expressing six basic emotions and their association with the RT dose to the amygdala-orbitofrontal network. ERT outcomes included the median time to choose a response (ERTOMDRT) or correct response (ERTOMDCRT) and total correct responses (ERTHH).
Results: The RT dose to the amygdala-orbitofrontal network was significantly associated with longer median response times on the ERT. Increases in median response times occurred at lower doses than decreases in total correct responses. The medial orbitofrontal cortex was the most important variable on regression trees predicting change in the ERTOMDCRT.
Discussion: This is, to our knowledge, the first study to show that off-target RT dose to the amygdala-orbitofrontal network is associated with performance on a social cognition task, a facet of cognition that has previously not been mechanistically studied after cranial RT.