Safety and efficacy of superior turbinate biopsies as a source of olfactory epithelium appropriate for morphological analysis.
- Resource Type
- Academic Journal
- Authors
- Garcia ECD; Department of Clinical Surgery, Londrina State University (UEL), Londrina, PR, Brazil.; Rossaneis AC; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathological Sciences, UEL, Londrina, PR, Brazil.; Pipino AS; Department of Clinical Surgery, Londrina State University (UEL), Londrina, PR, Brazil.; Gomes GV; Department of Clinical Surgery, Londrina State University (UEL), Londrina, PR, Brazil.; de Rezende Pinna F; Department of Otorhinolaryngology, University of São Paulo, São Paulo, SP, Brazil.; Voegels RL; Department of Otorhinolaryngology, University of São Paulo, São Paulo, SP, Brazil.; Doty RL; Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy and Cancer, Department of Pathological Sciences, UEL, Londrina, PR, Brazil.; Fornazieri MA; Department of Clinical Surgery, Londrina State University (UEL), Londrina, PR, Brazil. marcofornazieri@gmail.com.; Department of Otorhinolaryngology, University of São Paulo, São Paulo, SP, Brazil. marcofornazieri@gmail.com.; Department of Medicine, Pontifical Catholic University of Paraná, Londrina, Brazil. marcofornazieri@gmail.com.
- Source
- Publisher: Springer International Country of Publication: Germany NLM ID: 9002937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-4726 (Electronic) Linking ISSN: 09374477 NLM ISO Abbreviation: Eur Arch Otorhinolaryngol Subsets: MEDLINE
- Subject
- Language
- English
Purpose: There is no standardized approach for preserving olfactory function in the side of the nose where biopsy of the olfactory epithelium (OE) is performed. Moreover, a gold standard technique for obtaining human OE in vivo is still lacking. We determined the efficacy of obtaining good-quality OE specimens suitable for pathological analysis from the lower half of the superior turbinate and verified the safety of this procedure in maintaining bilateral and unilateral olfactory function.
Methods: In 21 individuals without olfactory complaints and who had undergone septoplasty and inferior turbinectomy OE biopsy was made during septoplasty. Olfactory function, both unilateral and bilateral, was assessed using the University of Pennsylvania Smell Identification Test (UPSIT) before and 1 month after the procedure. Specimens were marked with the olfactory marker protein for confirmation of OE presence.
Results: Ninety percent of the samples contained OE, although clear histological characterization was possible from only 62%. There was no deterioration of UPSIT scores either bilaterally or unilaterally on the side of the biopsy. Patients also maintained the ability to identify individual odorants.
Conclusion: Biopsies of the lower half of the superior turbinate do not affect olfactory function and show strong efficacy in yielding OE tissue and moderate efficacy for yielding tissue appropriate for morphological analysis. Future studies are needed to assess the safety of this procedure in other OE regions.