Background: Ambient air pollution has been associated with hypertensive disorders of pregnancy (HDP), but few studies rely on assessment of fine-scale variation in air quality, specific subtypes and multi-pollutant exposures.
Aim: To study the impact of long-term exposure to individual and mixture of air pollutants on all and specific subtypes of HDP.
Methods: We obtained data from 130,470 liveborn singleton pregnacies in Rome during 2014-2019. Spatiotemporal land-use random-forest models at 1 km spatial resolution assigned to the maternal residential addresses were used to estimate the exposure to particulate matter (PM 2.5 and PM 10 ), nitrogen dioxide (NO 2 ), and ozone (O 3 ).
Results: For PM 2.5, PM 10 and NO 2 , there was suggestive evidence of increased risk of preeclampsia (PE, n = 442), but no evidence of increased risk for all subtypes of HDP (n = 2297) and gestational hypertension (GH, n = 1901). For instance, an interquartile range of 7.0 μg/m 3 increase in PM 2.5 exposure during the first trimester of pregnancy was associated with an odds ratio (OR) of 1.06 (95% confidence interval: 0.81, 1.39) and 1.04 (0.92, 1.17) after adjustment for NO 2 and the corresponding results for a 15.7 μg/m 3 increase in NO 2 after adjustment for PM 2.5 were 1.11 (0.92, 1.34) for PE and 0.83 (0.76, 0.90) for HDP. Increased risks for HDP and GH were suggested for O 3 in single-pollutant models and for PM after adjustment for NO 2 , but all other associations were stable or attenuated in two-pollutant models.
Conclusions: The results of our study suggest that PM 2.5 , PM 10 and NO 2 increases the risk of PE and that these effects are robust to adjustment for O 3 while the increased risks for GH and HDP suggested for O 3 attenuated after adjustment for PM or NO 2 . Additional studies are needed to evaluate the effects of source-specific component of PM on subtypes as well as all types of HDP which would help to target preventive actions.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)