Index Case of Cutaneous Follicular Mycosis Fungoides With Central Nervous System Involvement and Review of Literature.
- Resource Type
- Academic Journal
- Authors
- Nguyen GH; Department of Dermatology, University of Colorado Anschutz Medical College, Aurora, CO.; Mohler A; Department of Neurology, Alpert Medical School, Brown University, Providence, RI.; Leppert M; Department of Neurology, University of Colorado Anschutz Medical College, Aurora, CO.; Parra C; Department of Dermatology, Weill Cornell Medical College, New York, NY.; Zeng YP; Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Prok L; Department of Dermatology, University of Colorado Anschutz Medical College, Aurora, CO.; Schowinsky J; Department of Pathology, University of Colorado Anschutz Medical College, Aurora, CO.; Magro CM; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY.; Pacheco T; Department of Dermatology, University of Colorado Anschutz Medical College, Aurora, CO.; Ney D; Department of Neurology, University of Colorado Anschutz Medical College, Aurora, CO.
- Source
- Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7911005 Publication Model: Print Cited Medium: Internet ISSN: 1533-0311 (Electronic) Linking ISSN: 01931091 NLM ISO Abbreviation: Am J Dermatopathol Subsets: MEDLINE
- Subject
- Language
- English
Central nervous system involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages of the disease. We describe a patient with early-stage follicular MF who presented with changes in mental status. Despite an initial diagnosis of vasculitis based on clinical and brain biopsy results, the postmortem examination revealed extensive infiltration of MF cells throughout the brain with leptomeningeal involvement. This case in addition to the accompanied review of literature illustrates the importance of the awareness of central nervous system involvement by MF and highlights the need for an urgent neurologic evaluation in patients with a history of MF now presenting with neurologic signs or symptoms.