Background: Complete revascularization of coronary disease has been linked to improved outcomes in patients with preserved left ventricular (LV) function.
Objectives: To identify the impact of complete revascularization in patients with severe LV dysfunction.
Methods: Patients enrolled in the REVIVED-BCIS2 trial were eligible if baseline/procedural angiograms and viability studies were available for analysis by independent core laboratories. Anatomical and viability-guided completeness of revascularization were measured by the coronary and myocardial revascularization indices (RI coro and RI myo ) respectively, where RI coro =[change in BCIS Jeopardy Score (BCIS-JS)] / [baseline BCIS-JS] and RI myo =[number of revascularized viable segments] / [ number of viable segments supplied by diseased vessels]. The PCI group was classified as having complete or incomplete revascularization by median RI coro and RI myo . The primary outcome was death or hospitalization for heart failure.
Results: Of 700 randomized patients, 670 were included. The baseline BCIS-JS and SYNTAX scores were 8 (6 to 10) and 22 (15 to 29) respectively. In those assigned to PCI, median RI coro and RI myo values were 67% and 85%. Compared to the group assigned to optimal medical therapy alone, there was no difference in the likelihood of the primary outcome in those receiving complete anatomical or viability-guided revascularization (HR 0.90, 95% CI 0.62-1.32 and HR 0.95, 95% CI 0.66-1.35 respectively). A sensitivity analysis by residual SYNTAX score showed no association with outcome.
Conclusions: In patients with severe left ventricular dysfunction, neither complete anatomical nor viability-guided revascularization were associated with improved event-free survival compared to incomplete revascularization or treatment with medical therapy alone.
(Copyright © 2024. Published by Elsevier Inc.)