CD4 + T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12.
- Resource Type
- Academic Journal
- Authors
- Paust HJ; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Song N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; De Feo D; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland.; Asada N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Tuzlak S; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland.; Zhao Y; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg 20246, Germany.; Riedel JH; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hellmig M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Sivayoganathan A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Peters A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Kaffke A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Borchers A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Wenzel UO; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Steinmetz OM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Tiegs G; Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Meister E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Mack M; Department of Nephrology, University Hospital Regensburg, Regensburg 93042, Germany.; Kurts C; Institute of Molecular Medicine and Experimental Immunology, University Hospital Bonn, Bonn 53127, Germany.; von Vietinghoff S; Nephrology Section, Medical Clinic 1, University Hospital Bonn, Bonn 53127, Germany.; Lindenmeyer MT; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hoxha E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Stahl RAK; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Bonn S; Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Meyer-Schwesinger C; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Wiech T; Institute of Pathology, Division of Nephropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Turner JE; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Becher B; Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland.; Krebs CF; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Panzer U; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
- Source
- Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
- Subject
- Language
- English
GM-CSF in glomerulonephritisDespite glomerulonephritis being an immune-mediated disease, the contributions of individual immune cell types are not clear. To address this gap in knowledge, Paust et al . characterized pathological immune cells in samples from patients with glomerulonephritis and in samples from mice with the disease. The authors found that CD4+ T cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF) licensed monocytes to promote disease by producing matrix metalloproteinase 12 and disrupting the glomerular basement membrane. Targeting GM-CSF to inhibit this axis reduced disease severity in mice, implicating this cytokine as a potential therapeutic target for patients with glomerulonephritis. -CM.