Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis.
- Resource Type
- Academic Journal
- Authors
- Leslie JL; Department of Medicine, Division of International Health and Infectious Diseases, University of Virginia School of Medicine, Charlottesville, Virginia, USA.; Weddle E; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.; Yum LK; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.; Lin Y; Department of Statistics, University of Virginia, Charlottesville, Virginia, USA.; Jenior ML; Department of Biomedical Engineering, University of Virginia School of Medicine and School of Engineering, Charlottesville, Virginia, USA.; Lee B; Vaccine Testing Center and Department of Pediatrics, The University of Vermont College of Medicine, Burlington, Vermont, USA.; Ma JZ; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.; Kirkpatrick BD; Department of Medicine and Vaccine Testing Center, The University of Vermont College of Medicine, Burlington, Vermont, USA.; Nayak U; Center for Public Health Genomics and Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.; Platts-Mills JA; Department of Medicine, Division of International Health and Infectious Diseases, University of Virginia School of Medicine, Charlottesville, Virginia, USA.; Agaisse HF; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.; Haque R; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.; Petri WA; Department of Medicine, Division of International Health and Infectious Diseases, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
- Source
- Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
- Subject
- Language
- English
In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.
(© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.)