Pharmacokinetics derived from PET imaging of inspiring radio-enhancer platinum nanoparticles.
- Resource Type
- Academic Journal
- Authors
- Yang X; Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d'Orsay, 91405 Orsay, France. Electronic address: xiaominyangzzu@gmail.com.; Tran VL; Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay 91401, France. Electronic address: vl.tran@hotmail.com.; Remita H; Université Paris-Saclay, CNRS, Institut de Chimie Physique, 91405 Orsay, France. Electronic address: hynd.remita@universite-paris-saclay.fr.; Savina F; Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d'Orsay, 91405 Orsay, France. Electronic address: farah.savina@universite-paris-saclay.fr.; Denis C; Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay 91401, France. Electronic address: caroline.denis@universite-paris-saclay.fr.; Kereselidze D; Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay 91401, France. Electronic address: Dimitri.Kereselidze@universite-paris-saclay.fr.; Jego B; Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay 91401, France. Electronic address: benoit.jego@universite-paris-saclay.fr.; Lacombe S; Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d'Orsay, 91405 Orsay, France. Electronic address: sandrine.lacombe@universite-paris-saclay.fr.; Porcel E; Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d'Orsay, 91405 Orsay, France. Electronic address: erika.porcel@universite-paris-saclay.fr.; Truillet C; Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay 91401, France. Electronic address: charles.truillet@universite-paris-saclay.fr.
- Source
- Publisher: Elsevier Country of Publication: United States NLM ID: 101233142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-9642 (Electronic) Linking ISSN: 15499634 NLM ISO Abbreviation: Nanomedicine Subsets: MEDLINE
- Subject
- Language
- English
Personalized medicine approach in radiotherapy requires the delivery of precise dose to the tumor. The concept is to increase the effectiveness of radiotherapy while sparing the surrounding heathy tissue. This can be achieved by the use of high-Z metal-based nanoparticles (NPs) as radio-enhancers and PET imaging for mapping NPs distribution to guide the irradiation. In the present study, radio-enhancing platinum NPs were radiolabeled and imaged to assess their pharmacokinetics over time. PET imaging of these NPs revealed high enhanced permeation and retention effect. The maximal tumor accumulation (4.8 ± 0.8 %ID/cc) was observed at 24 h post-injection along with persistent accumulation of the NPs, especially at the tumor ring, even after several days. These properties positively suggest the potential clinical use of these NPs.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2022. Published by Elsevier Inc.)