Differing effects of estrogen deficiency on the contractile function of atrial and ventricular myocardium.
- Resource Type
- Academic Journal
- Authors
- Khokhlova A; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia. Electronic address: a.d.khokhlova@urfu.ru.; Myachina T; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.; Butova X; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.; Volzhaninov D; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.; Berg V; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.; Kochurova A; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.; Kuznetsov D; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.; Mukhlynina E; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.; Kopylova G; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.; Shchepkin D; Institute of Immunology and Physiology, Russian Academy of Sciences, Pervomajskaya 106, 620049, Yekaterinburg, Russia.
- Source
- Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
- Subject
- Language
- English
Estrogen deficiency has a significant influence on the excitation-contraction coupling in the ventricular myocardium but its impact on the atrial contractile function has not been studied. We have compared the effects of estrogen deficiency on the contractility and cytosolic Ca 2+ transient of single cardiomyocytes isolated from the left atrium (LA) and the left ventricle (LV) of rats subjected to ovariectomy (OVX) or sham surgery (Sham). The characteristics of actin-myosin interaction were studied in an in vitro motility assay. We found that OVX decreased the contractility of LV single cardiomyocytes but increased that of LA myocytes. The disturbance of ventricular mechanical function may be explained by the acceleration of Ca 2+ transient and reduced Ca 2+ sensitivity of the actin-myosin interaction. The augmentation of LA contractility may be explained by accelerated cross-bridge kinetics and increased end-diastolic sarcomere length, which may lead to elevated tension in atrial cells due to the Frank-Starling mechanism.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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