Understanding Mechanisms of Response to CAR T-cell Therapy through Single-Cell Sequencing: Insights and Challenges.
- Resource Type
- Academic Journal
- Authors
- Haradhvala NJ; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Maus MV; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts.
- Source
- Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE
- Subject
- Language
- English
Summary: Single-cell RNA sequencing has emerged as a powerful technique to understand the molecular features of chimeric antigen receptor (CAR) T cells that associate with clinical outcomes. Here we discuss the common themes that have emerged from across single-cell studies of CAR T-cell therapy, and summarize the challenges in interpreting this complex data type.
(©2024 American Association for Cancer Research.)