A Discordant Pattern of Uptake on 68 Ga-PSMA PET/CT Versus 18 F-Fluciclovine PET/CT in Radiation-Induced Hepatitis : Implications for Early Postradiotherapy Imaging-Based Response Assessment.
- Resource Type
- Academic Journal
- Authors
- Adediran OA; From the Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.; Lawal IO; Muzahir S; From the Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.; Bhave MA; Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.; Friend S; Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.; Fielder B; From the Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.; Meisel J; Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.; Torres MA; Department of Radiation Oncology, Emory University, Atlanta, GA.; Styblo TM; Department of Surgery, Emory University, Atlanta, GA.; Graham C; Department of Surgery, Emory University, Atlanta, GA.; Holbrook A; From the Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.; Kalinsky K; Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.; Crowe RJ; Emory Centre for Systems Imaging Core, Emory University, Atlanta, GA.; Ulaner GA; Molecular Imaging and Therapy, Hoag Family Cancer Institute, Newport Beach, CA.; Schuster DM; From the Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.
- Source
- Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE
- Subject
- Language
- English
Abstract: A 62-year-old woman with right-sided invasive lobular breast carcinoma completed external beam radiotherapy 6 weeks before undergoing a 68 Ga-PSMA PET/CT and 18 F-fluciclovine PET/CT scan as part of an ongoing clinical trial (NCT04750473) assessing the performance of these molecular imaging modalities in invasive lobular breast carcinoma. The 68 Ga-PSMA PET/CT demonstrated a band-like area of increased radiotracer uptake in the dome of the right lobe of the liver anteriorly, whereas 18 F-fluciclovine PET/CT done a day later revealed photopenia in the corresponding area of the liver. The external beam radiotherapy plan confirmed that the radiotherapy field overlaid the region of the hepatic discordant radiotracer uptake on the PET/CT scans.
Competing Interests: Conflicts of interest and sources of funding: Fluciclovine doses were provided by Blue Earth Diagnostics, Inc. PSMA-11 cold kits were provided by Telix Pharmaceuticals (US) Inc. Study funded by NIH R21CA256280.
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