Mitochondrial-targeted antioxidant ingestion acutely blunts VO 2max in physically inactive females.
- Resource Type
- Academic Journal
- Authors
- Hughes RP; Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, Indiana, USA.; Carlini NA; Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, Indiana, USA.; Fleenor BS; Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, Indiana, USA.; Harber MP; Clinical Exercise Physiology, Human Performance Laboratory, Ball State University, Muncie, Indiana, USA.
- Source
- Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE
- Subject
- Language
- English
Purpose: To determine the acute effects of a mitochondrial targeting antioxidant (MitoQ) on the metabolic response during exercise.
Methods: Nine (n = 9) physically inactive females (age 47 ± 22 years) performed two trials (Placebo and MitoQ) in a double-blind randomized cross-over design. In both trials, participants performed an exercise protocol consisting of 3-min stages at submaximal workloads followed by a ramp protocol to volitional exhaustion. Participants received either Placebo or MitoQ (80 mg) 1 h prior to exercise. Indirect calorimetry and cardiovascular measurements were collected throughout the duration of the exercise bout.
Results: Submaximal metabolic and cardiovascular variables were not different between trials (p > 0.05). VO 2max was higher (p = 0.03) during Placebo (23.5 ± 5.7 mL kg min -1 ) compared to MitoQ (21.0 ± 6.6 mL kg min -1 ). Maximal ventilation was also higher (p = 0.02) in Placebo (82.4 ± 17.7 L/min) compared to MitoQ (75.0 ± 16.8 L/min). Maximal cardiovascular variables and blood lactate were not different between trials (p > 0.05).
Conclusion: An acute dose of MitoQ blunted VO 2max , which was primarily mediated by impairment of ventilatory function. These data suggest that the acute accumulation of exercise-induced mitochondrial reactive oxygen species (mtROS) are necessary for maximal aerobic capacity. Further research is warranted on mtROS-antioxidant cell signaling cascades, and how they relate to mitochondrial function during exercise.
(© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)