Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March-April 2021.
- Resource Type
- Academic Journal
- Authors
- Moline HL; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Keaton A; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Rice W; Virginia Beach Health Department, Virginia Beach, Virginia, USA.; Varghese J; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Deng L; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Waters A; Council of State and Territorial Epidemiologists,, Atlanta, GA, USA.; Virginia Department of Health, Richmond, Virginia, USA.; Barringer A; Virginia Beach Health Department, Virginia Beach, Virginia, USA.; Winston D; Virginia Beach Health Department, Virginia Beach, Virginia, USA.; Fields V; Virginia Department of Health, Richmond, Virginia, USA.; Slifka KJ; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Verani JR; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Schrag SJ; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Jernigan J; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Tate JE; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Fleming-Dutra KE; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
- Source
- Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
- Subject
- Language
- English
In April 2021, we assessed mRNA vaccine effectiveness (VE) in the context of a COVID-19 outbreak in a skilled nursing facility. Among 28 cases, genomic sequencing was performed on 4 specimens on 4 different patients, and all were classified by sequence analysis as the Beta (B.1.351) variant. Adjusted VE among residents was 65% (95% confidence interval: 25-84%). These findings underscore the importance of vaccination for prevention of COVID-19 in skilled nursing facilities.
Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
(Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.)