Recurrent HLA-B56 mediated neonatal alloimmune thrombocytopenia with fatal outcomes.
- Resource Type
- Academic Journal
- Authors
- Hutchinson AL; Australian Red Cross Blood Service, Sydney, Australia. Electronic address: anna.ostberg@gmail.com.; Dennington PM; Australian Red Cross Blood Service, Sydney, Australia.; Holdsworth R; Australian Red Cross Blood Service, Sydney, Australia.; Downe L; Nepean Hospital, Sydney, Australia.
- Source
- Publisher: Pergamon Country of Publication: England NLM ID: 101095653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0502 (Print) Linking ISSN: 14730502 NLM ISO Abbreviation: Transfus Apher Sci
- Subject
- Language
- English
- ISSN
- 1473-0502
Neonatal alloimmune thrombocytopenia is caused by maternal antibodies against paternally-inherited alloantigens present on foetal platelets and is a significant cause of morbidity and mortality in neonates. While generally thought of as a human platelet antibody mediated phenomenon, cases of HLA mediated NAIT have been reported. We document the investigation of a patient with two pregnancies affected by HLA-B56 mediated NAIT and a proposal for management of future pregnancies.
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