Associations among hypertension, dementia biomarkers, and cognition: The MEMENTO cohort.
- Resource Type
- Academic Journal
- Authors
- Lespinasse J; Inserm Research Center « Bordeaux Population Health », Bordeaux School of Public Health, CIC 1401-EC, Bordeaux University, Bordeaux, France.; Pôle de santé publique, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.; Chêne G; Inserm Research Center « Bordeaux Population Health », Bordeaux School of Public Health, CIC 1401-EC, Bordeaux University, Bordeaux, France.; Pôle de santé publique, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.; Mangin JF; CATI, US52-UAR2031, CEA, ICM, SU, CNRS, INSERM, APHP, Paris, France.; Université Paris-Saclay, CEA, CNRS, Neurospin, UMR9027 Baobab, Gif-sur-Yvette, France.; Dubois B; Sorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France.; Sorbonne-Université, Service des maladies cognitives et comportementales et Institut de la mémoire et de la maladie d'Alzheimer (IM2A), Hôpital de la Salpêtrière, Paris AP-PH, France.; Blanc F; Univ. Strasbourg, CNRS, ICube laboratory, UMR 7357, Fédération de Médecine Translationnelle de Strasbourg, Centre Mémoire de Ressources et de Recherches, Departement de Gériatrie, Strasbourg, France.; Paquet C; Univ. Paris, Inserm U1144, GHU APHP Nord Lariboisière Fernand-Widal, Paris, France.; Hanon O; Univ. de Paris, EA 4468, Service de Gériatrie, AP-HP, Hôpital Broca, Paris, France.; Planche V; Univ. Bordeaux, CNRS UMR 5293, Institut des Maladies Neurodégénératives, Centre Mémoire de Ressources et de Recherches, Pôle de Neurosciences Cliniques, CHU de Bordeaux, Bordeaux, France.; Gabelle A; Univ. Montpellier, i-site MUSE, Inserm U1061, Centre Mémoire de Ressources et de Recherches, Pôle de Neurosciences, Département de Neurologie, CHU de Montpellier, Montpellier, France.; Ceccaldi M; Univ. Aix Marseille, Inserm UMR 1106, Institut de Neurosciences des Systèmes, Centre Mémoire de Ressources et de Recherches, Département de Neurologie et de Neuropsychologie, AP-HM, Marseille, France.; Annweiler C; Univ. Angers, UPRES EA 4638, Centre Mémoire de Ressources et de Recherches, Département de Gériatrie, CHU d'Angers, Angers, France.; Krolak-Salmon P; Univ. Lyon, Inserm U1028, CNRS UMR5292, Centre de Recherche en Neurosciences de Lyon, Centre Mémoire Ressource et Recherche de Lyon (CMRR), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.; Godefroy O; Neurology Departement and Functional Neurosciences Lab. (UR UPJV 4559), Amiens University Hospital, Amiens, France.; Wallon D; Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, CIC-CRB1404, Rouen, France.; Sauvée M; CMRR Grenoble Arc Alpin, CHU Grenoble, Grenoble, France.; Laboratoire de Psychologie et NeuroCognition: LPNC CNRS 5105, Université Grenoble Alpes, Grenoble, France.; Bergeret S; Département de Médecine Nucléaire, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.; Chupin M; CATI, US52-UAR2031, CEA, ICM, SU, CNRS, INSERM, APHP, Paris, France.; Proust-Lima C; Inserm Research Center « Bordeaux Population Health », Bordeaux School of Public Health, CIC 1401-EC, Bordeaux University, Bordeaux, France.; Dufouil C; Inserm Research Center « Bordeaux Population Health », Bordeaux School of Public Health, CIC 1401-EC, Bordeaux University, Bordeaux, France.; Pôle de santé publique, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.
- Source
- Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
- Subject
- Language
- English
Introduction: Approximately 40% of dementia cases could be delayed or prevented acting on modifiable risk factors including hypertension. However, the mechanisms underlying the hypertension-dementia association are still poorly understood.
Methods: We conducted a cross-sectional analysis in 2048 patients from the MEMENTO cohort, a French multicenter clinic-based study of outpatients with either isolated cognitive complaints or mild cognitive impairment. Exposure to hypertension was defined as a combination of high blood pressure (BP) status and antihypertensive treatment intake. Pathway associations were examined through structural equation modeling integrating extensive collection of neuroimaging biomarkers and clinical data.
Results: Participants treated with high BP had significantly lower cognition compared to the others. This association was mediated by higher neurodegeneration and higher white matter hyperintensities load but not by Alzheimer's disease (AD) biomarkers.
Discussion: These results highlight the importance of controlling hypertension for prevention of cognitive decline and offer new insights on mechanisms underlying the hypertension-dementia association.
Highlights: Paths of hypertension-cognition association were assessed by structural equation models. The hypertension-cognition association is not mediated by Alzheimer's disease biomarkers. The hypertension-cognition association is mediated by neurodegeneration and leukoaraiosis. Lower cognition was limited to participants treated with uncontrolled blood pressure. Blood pressure control could contribute to promote healthier brain aging.
(© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)