Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes.
- Resource Type
- Academic Journal
- Authors
- Alraies Z; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Rivera CA; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Delgado MG; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Sanséau D; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Maurin M; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Amadio R; Cellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.; Maria Piperno G; Cellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.; Dunsmore G; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.; Yatim A; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Lacerda Mariano L; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Kniazeva A; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Calmettes V; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Sáez PJ; Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Williart A; CNRS UMR144, Institut Curie, PSL Research University, Paris, France.; Popard H; CNRS UMR144, Institut Curie, PSL Research University, Paris, France.; Gratia M; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Lamiable O; Malaghan Institute of Medical Research, Wellington, New Zealand.; Moreau A; Center for Research in Transplantation and Translational Immunology, UMR 1064, INSERM, Nantes Université, Nantes, France.; Fusilier Z; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; INSERM U932, Immunity and Cancer, Institut Curie, Paris-Cité University, Paris, France.; Crestey L; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Albaud B; Platform NGS-ICGEX, Institut Curie, Paris, France.; Legoix P; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Dejean AS; INSERM UMR1291, CNRS UMR5051, Institut Toulousain des Maladies Infectieuses et Inflammatoires (INFINITy), Université Toulouse III, Toulouse, France.; Le Dorze AL; INSERM UMR1291, CNRS UMR5051, Institut Toulousain des Maladies Infectieuses et Inflammatoires (INFINITy), Université Toulouse III, Toulouse, France.; Nakano H; Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA.; Cook DN; Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA.; Lawrence T; Centre d'Immunologie de Marseille-Luminy, INSERM, CNRS, Université Aix-Marseille, Marseille, France.; Centre for Inflammation Biology and Cancer Immunology, School of Immunology and Microbial Sciences, King's College London, London, UK.; Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.; Manel N; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; Benvenuti F; Cellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.; Ginhoux F; INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR), 8A Biomedical Grove, Immunos, Singapore, Singapore.; Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.; Moreau HD; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.; P F Nader G; CNRS UMR144, Institut Curie, PSL Research University, Paris, France.; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Piel M; CNRS UMR144, Institut Curie, PSL Research University, Paris, France. matthieu.piel@curie.fr.; Lennon-Duménil AM; INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France. ana-maria.lennon@curie.fr.
- Source
- Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
- Subject
- Language
- English
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformation events using dedicated shape-sensing pathways. However, how shape sensing affects immune cell function is mostly unknown. Here, we identify a shape-sensing mechanism that increases the expression of the chemokine receptor CCR7 and guides dendritic cell migration from peripheral tissues to lymph nodes at steady state. This mechanism relies on the lipid metabolism enzyme cPLA 2 , requires nuclear envelope tensioning and is finely tuned by the ARP2/3 actin nucleation complex. We also show that this shape-sensing axis reprograms dendritic cell transcription by activating an IKKβ-NF-κB-dependent pathway known to control their tolerogenic potential. These results indicate that cell shape changes experienced by immune cells can define their migratory behavior and immunoregulatory properties and reveal a contribution of the physical properties of tissues to adaptive immunity.
(© 2024. The Author(s).)