Molecular mechanisms regulating NETosis in infection and disease.
- Resource Type
- Academic Journal
- Authors
- Branzk N; Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, Mill Hill, London, UK.; Papayannopoulos V
- Source
- Publisher: Springer Country of Publication: Germany NLM ID: 101308769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-2300 (Electronic) Linking ISSN: 18632297 NLM ISO Abbreviation: Semin Immunopathol Subsets: MEDLINE
- Subject
- Language
- English
Neutrophils are the foot soldiers of the immune system. They home in to the site of infection and kill pathogens by phagocytosis, degranulation, and the release of web-like structures called neutrophil extracellular traps (NETs) that trap and kill a variety of microbes. NETs have been shown to play a multitude of additional roles in immunity but have also been implicated in inflammatory and autoimmune disease. Here, we discuss the role of NETs in these various contexts with a particular emphasis on the molecular mechanisms that regulate NET release and clearance. We highlight the comprehensive concepts and explore the important open questions in the field.