Unusual presentation of antisynthetase syndrome: a case series and review of the literature.
- Resource Type
- Academic Journal
- Authors
- Estrada-Maya J; Internal Medicine, Fundación Cardioinfantil-Instituto de Cardiología, Calle 163ª#13B-60, Bogotá, Colombia.; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.; de Los Ángeles Cuellar M; Internal Medicine, Fundación Cardioinfantil-Instituto de Cardiología, Calle 163ª#13B-60, Bogotá, Colombia.; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.; Vargas LP; Internal Medicine, Fundación Cardioinfantil-Instituto de Cardiología, Calle 163ª#13B-60, Bogotá, Colombia. linapccvargas@hotmail.com.; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia. linapccvargas@hotmail.com.; Gómez CC; Internal Medicine, Fundación Cardioinfantil-Instituto de Cardiología, Calle 163ª#13B-60, Bogotá, Colombia.; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.; Bonilla A; Internal Medicine, Fundación Cardioinfantil-Instituto de Cardiología, Calle 163ª#13B-60, Bogotá, Colombia.; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.; Burgos PF; Internal Medicine, Fundación Cardioinfantil-Instituto de Cardiología, Calle 163ª#13B-60, Bogotá, Colombia.; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.; Bedoya SA; Internal Medicine, Fundación Cardioinfantil-Instituto de Cardiología, Calle 163ª#13B-60, Bogotá, Colombia.; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.; Oliver MV; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.; Molano N; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.; Linares JS; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
- Source
- Publisher: BioMed Central Country of Publication: England NLM ID: 101293382 Publication Model: Electronic Cited Medium: Internet ISSN: 1752-1947 (Electronic) Linking ISSN: 17521947 NLM ISO Abbreviation: J Med Case Rep Subsets: MEDLINE
- Subject
- Language
- English
Background: Antisynthetase syndrome is an inflammatory myopathy that is characterized by the presence of anti-aminoacyl-tRNA synthetase antibodies. Only 30% of those who suffer from the disease can be identified. We present three Hispanic cases of antisynthetase syndrome with unusual clinical pictures were extended myositis panel results enable disease diagnosis and treatment.
Case Presentation: A 57-year-old Hispanic/Latino female with an erythematous scaly plaque, unresolved fever and non-immune haemolytic anaemia in whom inpatient work-up for fever of unknown origin was positive for anti-PL12 positive myositis extended panel. A 72-year-old Hispanic/Latino male with amyopathic weakness syndrome and mechanic hands in whom impatient work-up was relevant for proximal muscle uptake and anti-PM75 and AntiPL-12 myositis extended panel. And a 67-year-old Hispanic/Latino male with progressive interstitial lung disease and unresolved fever ended in myositis extended panel positive for antiPL-7. After systemic immunosuppressor treatment, patients had favourable clinical and paraclinical responses during outpatient follow-up.
Conclusions: The high variability of the antisynthetase syndrome in these cases demonstrates the importance of identification through an expanded panel and highlights the probability that this is a variable disease and that we need to include emerging molecular tests to promote the timely treatment of patients.
(© 2023. The Author(s).)