A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold.
- Resource Type
- Academic Journal
- Authors
- Batoni E; Research Center E. Piaggio, Department of Information Engineering, University of Pisa, 56122 Pisa, Italy.; Bonatti AF; Research Center E. Piaggio, Department of Information Engineering, University of Pisa, 56122 Pisa, Italy.; De Maria C; Research Center E. Piaggio, Department of Information Engineering, University of Pisa, 56122 Pisa, Italy.; Dalgarno K; School of Engineering, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.; Naseem R; School of Engineering, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.; Dianzani U; Department of Health Sciences, Università de Piemonte Orientale, 28100 Novara, Italy.; Gigliotti CL; Department of Health Sciences, Università de Piemonte Orientale, 28100 Novara, Italy.; NOVAICOS s.r.l.s, Via Amico Canobio 4/6, 28100 Novara, Italy.; Boggio E; Department of Health Sciences, Università de Piemonte Orientale, 28100 Novara, Italy.; NOVAICOS s.r.l.s, Via Amico Canobio 4/6, 28100 Novara, Italy.; Vozzi G; Research Center E. Piaggio, Department of Information Engineering, University of Pisa, 56122 Pisa, Italy.
- Source
- Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 1999-4923
This work presents a computational model to study the degradation behavior of polyester-based three-dimensional (3D) functionalized scaffolds for bone regeneration. As a case study, we investigated the behavior of a 3D-printed scaffold presenting a functionalized surface with ICOS-Fc, a bioactive protein able to stimulate bone regeneration and healing, inhibiting osteoclast activity. The aim of the model was to optimize the scaffold design to control its degradation and thus the release of grafted protein over time and space. Two different scenarios were considered: (i) a scaffold without macroporosity presenting a functionalized external surface; and (ii) a scaffold presenting an internal functionalized macroporous architecture with open channels to locally deliver the degradation products.