Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls.
- Resource Type
- Academic Journal
- Authors
- Thunnissen E; Department of Pathology, Amsterdam University Medical Center, Location Vumc.; Noguchi M; Department of Pathology, Naritatomisato Tokushukai Hospital, Chiba.; Berezowska S; Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Papotti MG; Department of Oncology, University of Turin.; Filipello F; Department of Pathology, Michele and Pietro Ferrero Hospital, Verduno (CN) and IRCCS San Raffaele Scientific Institute, Milan, Italy.; Minami Y; Department of Pathology, National Hospital Organization Ibarakihigashi National Hospital, The Center of Chest Diseases and Severe Motor & Intellectual Disabilities, Tokai, Ibaraki, Japan.; Blaauwgeers H; Department of Pathology, OLVG LAB BV, Amsterdam, The Netherlands.
- Source
- Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9435676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4031 (Electronic) Linking ISSN: 10724109 NLM ISO Abbreviation: Adv Anat Pathol Subsets: MEDLINE
- Subject
- Language
- English
Reproducibility of pulmonary invasive adenocarcinoma diagnosis is poor when applying the World Health Organization (WHO) classification. In this article, we aimed first to explain by 3-dimensional morphology why simple pattern recognition induces pitfalls for the assessment of invasion as applied in the current WHO classification of pulmonary adenocarcinomas. The underlying iatrogenic-induced morphologic alterations in collapsed adenocarcinoma in situ overlap with criteria for invasive adenocarcinoma. Pitfalls in seemingly acinar and papillary carcinoma are addressed with additional cytokeratin 7 and elastin stains. In addition, we provide more stringent criteria for a better reproducible and likely generalizable classification.
Competing Interests: The authors have no funding or conflicts of interest to disclose.
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