[Medical abortion using methotrexate and misoprostol. Efficacy and tolerability].
- Resource Type
- Academic Journal
- Authors
- Iamakov K; Pekhlivanov B; Amaliev I
- Source
- Publisher: Meditsina I Fizkultura Country of Publication: Bulgaria NLM ID: 0370455 Publication Model: Print Cited Medium: Print ISSN: 0324-0959 (Print) Linking ISSN: 03240959 NLM ISO Abbreviation: Akush Ginekol (Sofiia) Subsets: MEDLINE
- Subject
- Language
- Bulgarian
- ISSN
- 0324-0959
Unlabelled: Medical abortion means interruption of early pregnancy (usually before 9-th gestational week) as a result of administration of abortifacient drugs without surgical intervention.
Objective: To investigate the efficacy and tolerability of methotrexate plus misoprostol regimen as a method for early medical abortion < 49 days L.M.P.
Material and Method: 50 mg methotrexate was administered orally to 20 women < 49 days L.M.P. followed by 800 mcg misoprostol vaginal and oral administration 3-7 days after the methotrexate.
Results: 19 Successful medical abortions (95%). One woman chose vacuum aspiration for termination of the abortion on day 3 of the induced bleeding. No serious side effects were observed after administration of the drugs.
Conclusion: Medical abortion with methotrexate and misoprostol is safe and effective and can be offered to practicing gynecologists.