RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection.
- Resource Type
- Academic Journal
- Authors
- Lewitus E; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Sanders-Buell E; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Bose M; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; O'Sullivan AM; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Poltavee K; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Li Y; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Bai H; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Mdluli T; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Donofrio G; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Slike B; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Zhao H; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.; Wong K; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.; Chen L; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.; Miller S; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Lee J; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Ahani B; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Lepore S; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Muhammad S; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Grande R; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Tran U; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Dussupt V; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Mendez-Rivera L; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Nitayaphan S; US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.; Kaewkungwal J; US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.; Pitisuttithum P; Mahidol University, Nakhon Pathom, Thailand.; Rerks-Ngarm S; Thai Ministry of Public Health, Nonthaburi, Thailand.; O'Connell RJ; US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.; Janes H; Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.; Gilbert PB; Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.; Gramzinski R; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Vasan S; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Robb ML; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Michael NL; Center for Infectious Disease Research, WRAIR, Silver Spring, MD 20910, USA.; Krebs SJ; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Herbeck JT; Department of Global Health, University of Washington, Seattle, WA 98195, USA.; Edlefsen PT; Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.; Mullins JI; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.; Kim JH; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Tovanabutra S; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.; Rolland M; US Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
- Source
- Publisher: Oxford University Press Country of Publication: England NLM ID: 101664675 Publication Model: eCollection Cited Medium: Print ISSN: 2057-1577 (Print) Linking ISSN: 20571577 NLM ISO Abbreviation: Virus Evol Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2057-1577
The scale of the HIV-1 epidemic underscores the need for a vaccine. The multitude of circulating HIV-1 strains together with HIV-1's high evolvability hints that HIV-1 could adapt to a future vaccine. Here, we wanted to investigate the effect of vaccination on the evolution of the virus post-breakthrough infection. We analyzed 2,635 HIV-1 env sequences sampled up to a year post-diagnosis from 110 vaccine and placebo participants who became infected in the RV144 vaccine efficacy trial. We showed that the Env signature sites that were previously identified to distinguish vaccine and placebo participants were maintained over time. In addition, fewer sites were under diversifying selection in the vaccine group than in the placebo group. These results indicate that HIV-1 would possibly adapt to a vaccine upon its roll-out.
(© The Author(s) 2021. Published by Oxford University Press.)